Document Type : Research Paper
Ph.D. Student in Marine Biology, Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran
Department of Medical Mycology, AJA University of Medical Sciences, Tehran, Iran
In the present study, antifungal activity of Plakobranchus ocellatus collected from the southern waters of Qeshm Island in the Persian Gulf against Candida albicans. C. parapsilosis and C. glabrata, has been investigated. Acetonitrile, ethanol and phosphated buffer saline (PBS) as organic and aqueous extracts were prepared from the whole body tissue. The effects of seven concentrations of the extracts were tested through well-diffusion method. Maximum and minimum inhibition zones were estimated for acetonitrile and PBS extracts both in 2000 concentration (µg/ml) against C. parapsilosis and C. albicans, respectively. The most effects of extracted compounds were seen in 600, 900, 2000 and 3000 (µg/ml) concentrations. The aqaous extract compared with organic extract had a low effect that can be indicating a little amount of antifungal compounds with nature of protein and temperature-sensitive. In conclusion, it could be said to obtain the bioactive compounds in extracts with more inhibition diameter purification and extraction of secondary metabolites is necessary.